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Patients with vitiligo have low catalase levels in their epidermis in association with high levels of hydrogen peroxide. Topical application of a UVB-activated pseudocatalase cream can successfully remove epidermal H2O2 resulting in a remarkable repigmentation.
J Investig Dermatol Symp Proc 1999 Sep; 4(1):91-6
In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in
the epidermis of patients with vitiligo and its successful removal by a
UVB-activated pseudocatalase.Click here to access the PubMed abstract of
this article.
Researchers concluded that "although hydroquinone showed a better response, ascorbic acid may play a role in the therapy of melasma as it is almost devoid of side-effects; it could be used alone or in combination therapy."
Int J Dermatol. 2004 Aug;
43(8):604-7.
A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in
melasma.
Espinal-Perez LE, Moncada B, Castanedo-Cazares JP.Click here to access the PubMed abstract of
this article.
Melasma is a circumscribed brown macular hyperpigmentation of areas of the face and neck that are exposed to light, and is aggravated by sunlight, birth control pills, and pregnancy. This study demonstrates that a cream containing hydroquinone, glycolic acid, vitamins C and E, and sunscreen is a safe and effective treatment therapy for melasma.
Int J Dermatol. 2003 Dec; 42(12):966-72.
Safety and efficacy of 4% hydroquinone combined with 10% glycolic acid,
antioxidants, and sunscreen in the treatment of melasma.
Guevara IL, Pandya AG.Click here to access the PubMed abstract of
this article.
The antioxidant N-acetyl cysteine (NAC) has an antiproliferative effect on human keratinocytes and NAC has been used topically to satisfactorily treat lamellar ichthyosis.
Lancet. 1999 Nov 27; 354(9193):1880.
Topical N-acetylcysteine for lamellar ichthyosis.
Redondo P, Bauzá A.Click here to access the PubMed abstract of
this article.
Topically applied NAC can prevent skin irritation resulting from radiotherapy and protects from sun-induced erythema.
Semin Oncol. 1983 Mar; 10(1
Suppl 1):86-92.
Topical use of N-acetylcysteine for reduction of skin reaction to radiation
therapy.
Kim JA, Baker DG, Hahn SS, Goodchild
NT, Constable WC.Click here to access the PubMed abstract of
this article.
