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Pramoxine Reduces
Uremic Pruritus
Wake Forest
University School of Medicine conducted a randomized,
double-blind, controlled comparative trial in a community hemodialysis center
to evaluate the efficacy of 1% pramoxine hydrochloride lotion versus control
lotion in the treatment of uremic pruritus in adult hemodialysis patients.
Pramoxine 1% lotion was applied twice daily to all affected areas of pruritus
for 4 weeks, resulting in a 61% decrease in itch intensity. “This safe,
convenient and effective topical lotion may potentially benefit the large
number of patients affected by pruritus associated with end-stage renal
disease.”
J Dermatolog Treat. 2008 Sep 24:1-5.
A pramoxine-based anti-itch lotion is more effective than a control lotion
for the treatment of uremic pruritus in adult hemodialysis patients.Click here to access the PubMed abstract of
this article.
Hydroxyethyl
Starch-Induced Pruritus Relieved by Menthol/Camphor Lotion
Hydroxyethyl starch (HES) is a key component of many colloid volume expanders
used in hypovolemic shock and otologic disease. Pruritus is a common side
effect. Although classically refractory to treatment with corticosteroids and
antihistamines, some benefit has been achieved with topical capsaicin,
ultraviolet light therapy, and oral naltrexone.
A man with severe symptoms and refractory course was treated with a topical lotion
containing 0.5% camphor and 0.5% menthol, which was dramatically successful.
A randomised, double-blind, placebo-controlled trial showed a combination of
menthol and phenol to be beneficial in mustard-gas induced pruritis.
J Am Acad Dermatol. 2008 Jul; 59(1):151-3.
Hydroxyethyl starch-induced pruritus relieved by a combination of menthol
and camphor.Click here to access the PubMed abstract of
this article.
Singapore Med J 2007; 48:392-5.
Phenol and menthol in the treatment of chronic skin lesions following
mustard gas exposure.Click here to access the PubMed abstract of
this article.
Naltrexone
for Post-Burn Pruritus and Severe Generalized Pruritus in Biliary Atresia
“Severe pruritus is one of the many complications that burn survivors endure as
a consequence of healing or healed burn or donor site wounds,
“Naltrexone is a well-tolerated medication with little adverse effects [and]
may be an effective adjuvant treatment in the management of cholestatic
pruritus in the pediatric population.”
Two studies used a topical formulation of 1% naltrexone (or placebo) for 2 weeks to treat patients with localized and generalized atopic dermatitis with severe itching. More than 70% of the patients using the 1% naltrexone cream experienced a significant reduction of pruritus. The cream containing naltrexone had an overall 29.4% better effect than placebo.
Burns. 2008 Sep; 34(6):797-802. Epub 2008 Mar
5.
Naltrexone for the management of post-burn pruritus: A preliminary report.
LaSalle L, Rachelska G, Nedelec B.
[a href="http://www.ncbi.nlm.nih.gov/pubmed/18325676" target="_blank"]Click here to access the PubMed abstract of this article.
Pediatr Dermatol. 2008
May-Jun; 25(3):403-4.
The use of naltrexone in the management of severe generalized pruritus in
biliary atresia: report of a case.Click here to access the PubMed abstract of
this article.
J Am Acad Dermatol. 2007 Jun; 56(6):979-88
Treatment of pruritus with topically applied opiate receptor antagonist.Click here to access the PubMed abstract of
this article.
The following studies evaluated a topical formulation of 1% naltrexone to treat patients with localized and generalized atopic dermatitis with severe itching, and more than 70% of patients using the 1% naltrexone cream experienced a significant reduction of pruritus.
J Am Acad Dermatol. 2007
Jun; 56(6):979-88
Treatment of pruritus with topically applied opiate receptor antagonist.Click here to access the PubMed abstract of
this article.
J Cutan Med Surg. 2005 Oct; 9(5):215-6
Successful treatment of refractory aquagenic pruritus with naltrexone. Click here to access the PubMed abstract of
this article.
Itching Relieved with Topical Naltrexone
Pruritus is a very common and distressing skin problem. More than 70% of patients with localized and generalized atopic dermatitis with severe itching who used topical naltrexone 1% cream experienced a significant reduction of pruritus.
J Am Acad Dermatol. 2007 Jun; 56(6):979-88
Treatment of pruritus with topically applied opiate receptor antagonist.Click here to access the PubMed abstract of
this article.
Aquagenic pruritus is an intense prickling sensation that develops in affected individuals immediately after contact with water at any temperature. Endogenous opiates, like naltrexone, can modify pruritus by influencing the peripheral and central sensation of itch, and have been found to be successful in suppressing the perception of pruritus from many diverse origins including aquagenic pruritus.
J Cutan Med Surg. 2005
Oct;9(5):215-6
Successful treatment of refractory aquagenic pruritus with naltrexoneClick here to access the PubMed abstract of
this article.
